This paper reviews the role of surface roughness in the osteogenic response to implant
materials. Cells in the osteoblast lineage respond to roughness in cell-maturation-specific …

▪ Abstract Osteoblasts respond to surface topography with altered morphology, proliferation,
and differentiation. The effects observed vary with cell culture model and the topographical …

Earlier studies have shown that implant surface roughness influences osteoblast
proliferation, differentiation, matrix synthesis and local factor production. Moreover, the …

Background: Some patients who have a total hip replacement with a second-generation
metal-on-metal articulation have persistent or early recurrence of preoperative symptoms …

The success of an implant is determined by its integration into the tissue surrounding the
biomaterial. Surface roughness and composition are considered to influence the properties …

METHODS: To test this hypothesis, we examined the response of several cell models at
various states in the osteoblast lineage to titanium surfaces with smooth and rough …

Objective Hypertrophic chondrocyte differentiation is a key step in endochondral ossification
that produces basic calcium phosphates (BCPs). Although chondrocyte hypertrophy has …

Osteoblast phenotypic expression in monolayer culture depends on surface
microtopography. Here we tested the hypothesis that mineralized bone nodule formation in …

Titanium implant surfaces with rough microtopographies exhibit increased pullout strength in
vivo suggesting increased bone‐to‐implant contact. This is supported by in vitro studies …

Pulsed electromagnetic field stimulation has been used to promote the healing of chronic
nonunions and fractures with delayed healing, but relatively little is known about its effects …