The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the
Management of Glomerular Diseases is an update to the KDIGO 2012 guideline. The aim is …

SLE is a chronic inflammatory disease that affects the kidneys in about 50% of patients.
Lupus nephritis is a major risk factor for overall morbidity and mortality in SLE, and despite …

Systemic lupus erythematosus is a multisystem autoimmune disease that commonly affects
the kidneys. Lupus nephritis (LN) is the most common cause of kidney injury in systemic …

Glomerular disease, be it primary or secondary, occurring in the setting of systemic
autoimmune diseases, infections, drugs, or malignancy, affects individuals of all ages. In …

Segmental duplications in the human genome are selectively enriched for genes involved in
immunity, although the phenotypic consequences for host defense are unknown. We show …

Objective To evaluate the efficacy and safety of rituximab in a randomized, double‐blind,
placebo‐controlled phase III trial in patients with lupus nephritis treated concomitantly with …

Background Voclosporin, a novel calcineurin inhibitor approved for the treatment of adults
with lupus nephritis, improved complete renal response rates in patients with lupus nephritis …

Background In adults with active lupus nephritis, the efficacy and safety of intravenous
belimumab as compared with placebo, when added to standard therapy (mycophenolate …

Interindividual gene copy-number variation (CNV) of complement component C4 and its
associated polymorphisms in gene size (long and short) and protein isotypes (C4A and …

Two novel polymorphisms in the distal regulatory region of the MCP-1 gene were identified
by directly sequencing PCR amplified genomic DNA. These polymorphisms are located at …