Objective To investigate serum antibody reactivity against a panel of post-translationally
modified vimentin peptides (PTMPs) in patients with early inflammatory arthritis. Methods A …

Background Patients with systemic lupus erythematosus (SLE) are at an increased risk of
infection relative to the general population. We aimed to describe the frequency and risk …

Background Our knowledge of immune-mediated inflammatory disease (IMID) aetiology and
pathogenesis has improved greatly over recent years, however, very little is known of the …

Background: Immunoglobulin G4 related disease (IgG4-RD) is a multisystem immune-
mediated condition characterised by infiltration of IgG4-positive plasma cells into affected …

Background: Guidelines advise that patients with Difficult Asthma are managed by an
experienced Specialist Multidisciplinary Team (MDT). That often requires referral to a …

Discussion: We present these questions for discussion: 1) While tophaceous gout is now
clearly present, is Mr B's erosive polyarthropathy the result of untreated crystal arthropathy …

Discussion: Spinal involvement is well described in RA and the spondyloarthritides, but is
probably more common than previously reported amongst patients with calcium …

Background: Evidence for a 12 week window of opportunity after symptom onset, during
which therapeutic intervention meaningfully interrupts the natural history of RA, has led to a …

Introduction Autoinflammatory fever syndromes are rare and present significant diagnostic
and treatment challenges. We present a case which illustrates some key concepts regarding …

Background: Difficult Asthma poses significant management challenges. Better clinical
understanding of the nature of this state could facilitate better care. Aim: To aid …