Objectives A recent study identified 16 genetic variants associated with N-glycosylation of
human IgG. Several of the genomic regions where these single nucleotide polymorphisms …

Anti-tumour necrosis factor (TNF) agents have revolutionized the treatment of patients with
rheumatoid arthritis (RA). These therapies are, however, expensive and 30% of patients fail …

The FCGR locus encoding the low‐affinity Fcγ receptors (FcγR) for immunoglobulin G has
largely been missed by genome‐wide association studies due to complications with …

Background Despite the success of TNF-inhibitor therapy in rheumatoid arthritis treatment,
up to 40% of patients fail to respond adequately. This study aimed to identify transcriptome …

Aim: A genetic variant has recently reached genome-wide significance for association with
TNF-inhibitor response in rheumatoid arthritis patients. Here we undertake a replication …

Rheumatoid arthritis (RA) is characterised by chronic synovial joint inflammation. Treatment
has been revolutionised by tumour necrosis factor alpha inhibitors (TNFi) but each available …

Objectives Work is an important health outcome. This study aimed to identify predictors of
work loss, absenteeism and presenteeism over 1 year in RA patients commencing treatment …

Objective To investigate the association between socioeconomic deprivation and outcomes
following TNF inhibitor (TNFi) treatment. Methods Individuals commencing their first TNFi in …

Objective To determine whether using a reweighted disease activity score that better reflects
joint synovitis, ie, the 2‐component Disease Activity Score in 28 joints (DAS 28)(based on …

Objectives Interventions aimed at increasing TNF-α inhibitor serum drug levels (SDLs) may
improve treatment response; however, previous studies suggesting SDL cut-offs have not …