Musculoskeletal diseases, especially osteoarthritis (OA) and osteoporosis (OP), impair
activities of daily life (ADL) and quality of life (QOL) in the elderly. Although preventive …

Rheumatoid arthritis is a common inflammatory disease with complex genetic components.
We investigated the genetic contribution of the cytokine gene cluster in chromosome 5q31 to …

Abstract Osteoarthritis (MIM 165720), characterized by degeneration of articular cartilage, is
the most common form of human arthritis and a major concern for aging societies worldwide …

Chondrocyte hypertrophy followed by cartilage matrix degradation and vascular invasion,
characterized by expression of type X collagen (COL10A1), matrix metalloproteinase-13 …

Osteoarthritis is the most common form of human arthritis. We investigated the potential role
of asporin, an extracellular matrix component expressed abundantly in the articular cartilage …

Objective To regenerate permanent cartilage, it is crucial to know not only the necessary
conditions for chondrogenesis, but also the sufficient conditions. The objective of this study …

Objectives Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for
substantial morbidity and disability, particularly in older people. It is characterised by …

Objectives: Although lumbar spondylosis is a major cause of low back pain and disability in
elderly people, few epidemiological studies have been performed. The prevalence of …

To elucidate the molecular mechanism underlying the endochondral ossification process
during the skeletal growth and osteoarthritis (OA) development, we examined the signal …

Objective To investigate the risk of radiographic knee osteoarthritis (OA) and lumbar
spondylosis associated with occupational activity in elderly Japanese subjects using the …