Researchers have recently made advances in defining the pathogenesis of gout, including
elucidating its risk factors and tracing the molecular mechanisms of renal urate transport and …

▪ Abstract Early development of the vertebrate skeleton depends on genes that pattern the
distribution and proliferation of cells from cranial neural crest, sclerotomes, and lateral plate …

Gout is a common and very painful inflammatory arthritis caused by hyperuricaemia. This
Review provides an update on the genetics of hyperuricaemia and gout, including findings …

In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that
LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass …

Angiogenesis is an essential component of skeletal development and VEGF signaling plays
an important if not pivotal role in this process. Previous attempts to examine the roles of …

Objective To investigate the expression of the familial Mediterranean fever (FMF) gene
(MEFV) in human synovial fibroblasts. Methods MEFV messenger RNA in synovial …

Osteoarthritis (OA), one of the most common age-related chronic disorders of articular
cartilage, joints, and bone tissue, represents a major public health problem. Genetic studies …

Objectives To assess the reliability of the OMERACT ultrasound (US) definitions for the
identification of calcium pyrophosphate deposition disease (CPPD) at the metacarpal …

Objective The language currently used to describe gout lacks standardization. The aim of
this project was to develop a consensus statement on the labels and definitions used to …

Objective The objective of this consensus is to update the recommendations for the
treatment of hand, hip, and knee osteoarthritis (OA) by agreeing on key propositions relating …