Abstract
Population and peptide specificity analyses and studies in transgenic rodents support a role of HLA-B27 as an antigen-presenting molecule in spondyloarthropathy. The interplay between HLA-B27 and arthritogenic bacteria on infected cells suggests that HLA-B27 might also influence disease by other mechanisms. Recent genetic advances promise the identification of additional susceptibility genes.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Animals, Genetically Modified
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Arthritis / genetics*
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Arthritis / physiopathology*
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Bacterial Infections / immunology
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Chronic Disease
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Cysteine / immunology
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HLA-B27 Antigen / genetics
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HLA-B27 Antigen / immunology
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HLA-B27 Antigen / physiology*
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Humans
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Peptides / immunology
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Polymorphism, Genetic
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Spinal Diseases / immunology
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Spondylitis, Ankylosing / genetics
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Spondylitis, Ankylosing / physiopathology
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T-Lymphocytes / immunology
Substances
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HLA-B27 Antigen
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Peptides
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Cysteine