The U1 snRNP complex: an autoantigen in connective tissue diseases. An update

J M Klein Gunnewiek; L B van de Putte; W J van Venrooij

The U1 snRNP complex: an autoantigen in connective tissue diseases. An update

Clin Exp Rheumatol. 1997 Sep-Oct;15(5):549-60.

Authors

J M Klein Gunnewiek¹, L B van de Putte, W J van Venrooij

Affiliation

¹ Department of Biochemistry, University Hospital Nijmegen, The Netherlands.

PMID: 9307865

Abstract

The U1 small nuclear ribonucleoprotein (snRNP) particle consists of an RNA backbone and eleven associated proteins. Both the RNA and some of the proteins are immunogenic in patients suffering from systemic lupus erythematosus or mixed connective tissue disease. An overview is given of the U1 snRNP particle with respect to its structure and function as well as its autoantigenicity.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Autoantibodies / immunology*
Autoantigens / immunology*
Connective Tissue Diseases / immunology*
Humans
Ribonucleoprotein, U1 Small Nuclear / immunology*

Substances

Autoantibodies
Autoantigens
Ribonucleoprotein, U1 Small Nuclear