Abstract
Interleukin-10 (IL-10) has been described as an anti-inflammatory cytokine and B-cell proliferation factor and has been implicated in autoimmunity, tumorigenesis and transplantation tolerance. We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cells, Cultured
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Cytokines / genetics
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Gene Expression Regulation / immunology
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Gene Frequency / immunology
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Humans
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Interleukin-10 / biosynthesis
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Interleukin-10 / genetics*
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Lymphocytes
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Molecular Sequence Data
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Polymorphism, Genetic / immunology*
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Promoter Regions, Genetic / immunology*
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Sequence Analysis, DNA