Abstract
Thirty-nine patients with rheumatoid arthritis were HLA typed for the full range of A and B locus specificities and for Cw3 and Dw4. HLA-Dw4 was significantly more frequent in patients (36%) than in controls (13%). The frequency of Cw3 was also increased, probably because this allele is in linkage disequilibrium with Dw4.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Arthritis, Rheumatoid / genetics
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Arthritis, Rheumatoid / immunology*
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Female
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Gene Frequency
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Genetic Linkage
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HLA Antigens / analysis*
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Histocompatibility Antigens / analysis*
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Homozygote
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Humans
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Male
Substances
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HLA Antigens
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Histocompatibility Antigens