Abstract
Nerve growth factor (NGF) is increased during inflammation and stress. Stress-induced increases in specific serum proteins, such as serum amyloid A (SAA) and serum triglyceride (TG) levels, are part of the acute phase response which is mediated by cytokines. We now report the effect of systemic administration of beta-NGF on levels of serum lipids and SAA. Beta-NGF induced a rapid and sustained increase in serum TG and free fatty acid (FFA) in a dose dependent manner, while decreasing serum cholesterol levels in rats. Additionally, beta-NGF increased hepatic mRNA levels and serum concentrations of SAA at 16 hours in mice. Thus, beta-NGF joins the list of cytokines and growth factors that can mediate the acute phase response.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Cholesterol / blood*
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Cholesterol, HDL / blood
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Cholesterol, LDL / blood
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Dose-Response Relationship, Drug
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Humans
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Inflammation
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Liver / drug effects
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Liver / metabolism*
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Male
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Mice
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Mice, Inbred C57BL
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Nerve Growth Factors / pharmacology*
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Rats
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Rats, Sprague-Dawley
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Recombinant Proteins / pharmacology
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Reference Values
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Serum Amyloid A Protein / biosynthesis*
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Serum Amyloid A Protein / drug effects
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Stress, Physiological
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Triglycerides / blood
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Triglycerides / metabolism*
Substances
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Cholesterol, HDL
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Cholesterol, LDL
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Nerve Growth Factors
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Recombinant Proteins
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Serum Amyloid A Protein
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Triglycerides
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Cholesterol