Early detection of avascular necrosis of the femoral head by MRI

J Bone Joint Surg Br. 1993 May;75(3):365-7. doi: 10.1302/0301-620X.75B3.8496201.

Abstract

We used MRI to examine the hips of 32 asymptomatic patients at 9 to 21 months after renal transplantation covered by high-dose corticosteroids. Five hips in three patients showed changes which indicate avascular necrosis, although radiographs, CT scans and isotope scans were normal. These patients had repeat MRI scans after another two years and three years. One patient with bilateral MRI changes developed symptoms and abnormal radiographs and CT and isotope scans in one hip nine months after the abnormal MRI. Intraosseous pressure was found to be raised in both hips, and core biopsies revealed necrotic bone on both sides. The other three hips have remained asymptomatic with unchanged MRI appearances three years after the initial MRI. It seems that idiopathic avascular necrosis does not always progress to bone collapse in the medium term.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Biopsy
  • Female
  • Femur Head Necrosis / chemically induced
  • Femur Head Necrosis / diagnosis*
  • Femur Head Necrosis / epidemiology
  • Follow-Up Studies
  • Humans
  • Immunosuppression Therapy / adverse effects*
  • Kidney Transplantation / immunology*
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Postoperative Complications / chemically induced
  • Postoperative Complications / diagnosis*
  • Postoperative Complications / epidemiology
  • Prednisolone / administration & dosage
  • Prednisolone / adverse effects*
  • Sensitivity and Specificity
  • Technetium Tc 99m Medronate / analogs & derivatives
  • Tomography, X-Ray Computed

Substances

  • technetium Tc 99m hydroxymethylene diphosphonate
  • Prednisolone
  • Technetium Tc 99m Medronate