Quantitative microfocal radiography detects changes in erosion area in patients with early rheumatoid arthritis treated with myocrisine

J Rheumatol. 1993 Feb;20(2):243-7.

Abstract

Patients with early rheumatoid arthritis (RA) were randomly divided into those receiving gold early (n = 13) or 6 months later (n = 10). They were followed 6 monthly over 18 months. Mean erosion area in gold and delayed gold, measured from macroradiographs, was comparable at baseline and increased significantly over the first 6 months. In the second 6 months, gold showed no increase and delayed gold an insignificant increase. By the third 6 months both groups showed a decrease. On comparing the second 6 months of gold therapy in gold and delayed gold with a group of patients with RA of similar disease duration (n = 34) not receiving gold, a lower proportion (p < 0.005) had erosion area progression and a higher proportion (p < 0.001) erosion repair.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / diagnostic imaging*
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / pathology
  • Female
  • Finger Joint / diagnostic imaging
  • Finger Joint / pathology
  • Gold / administration & dosage
  • Gold / therapeutic use
  • Gold Sodium Thiomalate / therapeutic use*
  • Hand / diagnostic imaging
  • Hand / pathology
  • Humans
  • Male
  • Middle Aged
  • Radiography
  • Wrist Joint / diagnostic imaging
  • Wrist Joint / pathology

Substances

  • Gold Sodium Thiomalate
  • Gold