Long-term remission of neutropenia in Felty's syndrome after a short GM-CSF treatment

J Pereira; E D Velloso; H A Loterio; I M Laurindo; D A Chamone

doi:10.1159/000204209

Long-term remission of neutropenia in Felty's syndrome after a short GM-CSF treatment

Acta Haematol. 1994;92(3):154-6. doi: 10.1159/000204209.

Authors

J Pereira¹, E D Velloso, H A Loterio, I M Laurindo, D A Chamone

Affiliation

¹ Fundação Pró-Sangue/Hemocentro de São Paulo, Brazil.

PMID: 7871957
DOI: 10.1159/000204209

Abstract

We report a case of Felty's syndrome in which neutropenia was corrected by a short-term treatment with recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF, 5 micrograms/kg/day s.c. for 14 days). Absolute neutrophil counts rose from 0.1 to 2.2 x 10(9)/l and remained > 1.0 x 10(9)/l 8 weeks after discontinuation of the GM-CSF therapy. A flare-up of arthritis and a decrease in platelet counts were observed.

Publication types

Case Reports
Review

MeSH terms

Adult
Eosinophils / drug effects
Felty Syndrome / blood
Felty Syndrome / complications
Felty Syndrome / drug therapy*
Female
Granulocyte-Macrophage Colony-Stimulating Factor / administration & dosage*
Humans
Leukocyte Count / drug effects
Neutropenia / blood
Neutropenia / drug therapy*
Neutropenia / etiology
Neutrophils / drug effects
Recombinant Proteins / administration & dosage
Remission Induction
Time Factors

Substances

Recombinant Proteins
Granulocyte-Macrophage Colony-Stimulating Factor