Ossification of the posterior longitudinal ligament, diffuse, idiopathic skeletal hyperostosis, abnormal retinol and retinol binding protein: a familial observation

M De Bandt; O Meyer; J M Fuster; M F Kahn

Ossification of the posterior longitudinal ligament, diffuse, idiopathic skeletal hyperostosis, abnormal retinol and retinol binding protein: a familial observation

J Rheumatol. 1995 Jul;22(7):1395-8.

Authors

M De Bandt¹, O Meyer, J M Fuster, M F Kahn

Affiliation

¹ Rheumatology Unit, Hôpital Bichat, Paris, France.

PMID: 7562783

Abstract

We describe a 52-year-old man who presented with diffuse idiopathic skeletal hyperostosis, ossification of the posterior longitudinal ligament, and abnormal levels of retinol and retinol binding protein (RBP). The molar retinol/retinol binding protein ratio was high, suggesting congenital functional RBP deficiency. His two sons, aged 23 and 27 years, shared the same biological abnormality without clinical symptoms. To our knowledge, this is the first case report of such a familial association.

Publication types

Case Reports

MeSH terms

Humans
Hyperostosis, Diffuse Idiopathic Skeletal / blood
Hyperostosis, Diffuse Idiopathic Skeletal / complications*
Hyperostosis, Diffuse Idiopathic Skeletal / genetics
Male
Middle Aged
Ossification of Posterior Longitudinal Ligament / blood
Ossification of Posterior Longitudinal Ligament / complications*
Ossification of Posterior Longitudinal Ligament / genetics
Pedigree
Retinol-Binding Proteins / deficiency*
Vitamin A / blood*

Substances

Retinol-Binding Proteins
Vitamin A