Abstract
Extensive studies in different ethnic groups have associated the susceptibility to development of rheumatoid arthritis (RA) with the third hypervariable region of the major histocompatibility complex (MHC) HLA-DR beta 1 molecule. On the basis of recent findings in the experimental mouse model of collagen-induced arthritis, Eric Zanelli, Miguel Gonzalez-Gay and Chella David propose that the HLA-DRB1 locus is associated with protection to RA and that the actual arthritogenic peptide-presenting molecule is HLA-DQ. Thus, the development of RA would depend upon the expression of the susceptible DQ allele and the nonprotective DRB1 alleles, along with environmental factors that trigger the autoimmune process.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Animals
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Antigen Presentation
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Arthritis / chemically induced
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Arthritis / genetics
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Arthritis / immunology
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Arthritis, Rheumatoid / ethnology
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Arthritis, Rheumatoid / genetics*
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Arthritis, Rheumatoid / immunology
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Autoimmune Diseases / ethnology
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Autoimmune Diseases / genetics*
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Autoimmune Diseases / immunology
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Collagen / toxicity
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Disease Models, Animal
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Disease Susceptibility / ethnology
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Disease Susceptibility / immunology
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Diseases in Twins
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Epitopes / immunology
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Genetic Predisposition to Disease
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HLA-DQ Antigens / genetics
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HLA-DQ Antigens / immunology
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HLA-DQ beta-Chains
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HLA-DR Antigens / genetics*
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HLA-DR Antigens / immunology
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HLA-DRB1 Chains
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Histocompatibility Antigens Class II / genetics*
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Histocompatibility Antigens Class II / immunology
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Humans
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Mice
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Mice, Transgenic
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Polymorphism, Genetic
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T-Lymphocyte Subsets / immunology
Substances
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Epitopes
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HLA-DQ Antigens
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HLA-DQ beta-Chains
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HLA-DQB1 antigen
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HLA-DR Antigens
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HLA-DRB1 Chains
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Histocompatibility Antigens Class II
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I-E-antigen
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Collagen