Abstract
The clinical significance of antibodies to the Jo-1 antigen in connective tissue diseases was studied. Clinical diagnoses of 11 patients who had anti-Jo-1 antibody were: polymyositis 8, dermatomyositis 1, and overlap syndrome 2 (polymyositis--systemic lupus erythematosus 1, polymyositis--scleroderma 1). All the patients who had anti-Jo-1 antibody showed interstitial pulmonary fibrosis, and in 2 patients anti-Jo-1 antibodies were detected before the appearance of lung disease.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antibodies, Antinuclear / immunology*
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Antibody Specificity
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Autoantibodies / analysis*
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Connective Tissue Diseases / immunology*
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Creatine Kinase / blood
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Dermatomyositis / immunology
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Female
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Humans
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Immunodiffusion
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Male
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Middle Aged
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Myositis / complications
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Myositis / immunology
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Pulmonary Fibrosis / complications
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Pulmonary Fibrosis / immunology
Substances
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Antibodies, Antinuclear
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Autoantibodies
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Creatine Kinase