Degradation of type I and II collagen by human activated C1-s

K Yamaguchi; H Sakiyama; M Matsumoto; H Moriya; S Sakiyama

doi:10.1016/0014-5793(90)81009-d

Degradation of type I and II collagen by human activated C1-s

FEBS Lett. 1990 Jul 30;268(1):206-8. doi: 10.1016/0014-5793(90)81009-d.

Authors

K Yamaguchi¹, H Sakiyama, M Matsumoto, H Moriya, S Sakiyama

Affiliation

¹ Division of Physiology and Pathology, National Institute of Radiological Sciences, Chiba, Japan.

PMID: 2384156
DOI: 10.1016/0014-5793(90)81009-d

Abstract

The activated first component of human complement, C1-s, was shown to cleave type I and II collagen and gelatin. The proteolytic activity was heat labile and was inhibited by a monoclonal antibody (M241) which recognized light chain of active human C1-s or by a serine protease inhibitor, DFP, but not by a chelating agent.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Calcium
Collagen / metabolism*
Complement C1s / metabolism*
Enzyme Activation
Extracellular Matrix / metabolism
Humans
Molecular Sequence Data
Protease Inhibitors / pharmacology
Serine Endopeptidases / genetics
Serine Endopeptidases / metabolism

Substances

Protease Inhibitors
Collagen
Serine Endopeptidases
Complement C1s
Calcium