The CD70-CD27 axis, a new brake in the T helper 17 cell response

Immunity. 2013 Jan 24;38(1):1-3. doi: 10.1016/j.immuni.2013.01.005.

Abstract

The CD70-CD27 interaction is known to positively regulate T cell expansion and effector function by providing costimulatory signals. In this issue of Immunity, Coquet et al. (2013) show an unexpected T-helper-17-cell-specific negative regulation mediated by CD70-CD27 interaction.

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