Abstract
Nerve growth factor (NGF), a neurotrophin that plays a crucial role in promoting neurotrophic and neurotropic effects in sympathetic neurons, has recently been identified as a novel angiogenic molecule, which exerts a variety of effects in the cardiovascular system and on endothelial cells. In fact, NGF may contribute to maintenance, survival, and function of endothelial cells by autocrine and/or paracrine mechanisms. This review summarizes the involvement of NGF in the regulation of angiogenesis in both normal and pathological conditions.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Angiogenic Proteins / metabolism*
-
Animals
-
Cell Proliferation
-
Endothelial Cells / metabolism*
-
Humans
-
Ischemia / metabolism
-
Ischemia / physiopathology
-
Neoplasms / blood supply
-
Neoplasms / metabolism
-
Neoplasms / pathology
-
Neovascularization, Pathologic / metabolism
-
Neovascularization, Pathologic / physiopathology
-
Neovascularization, Physiologic*
-
Nerve Growth Factor / metabolism*
-
Signal Transduction
-
Vascular Endothelial Growth Factor A / metabolism
-
Wound Healing
Substances
-
Angiogenic Proteins
-
Vascular Endothelial Growth Factor A
-
Nerve Growth Factor