Abstract
In a double-blind crossover study lower esophageal sphincter pressure and distal esophageal motility were studied in 10 patients with progressive systemic sclerosis or mixed connective tissue disease, following a single intravenous dose of cisapride or placebo. The measurements were carried out under basal conditions and 30 min after intravenous administration of 10 mg cisapride or placebo. No effects on lower esophageal sphincter pressure or distal esophageal motility were observed.
Publication types
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Clinical Trial
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Controlled Clinical Trial
MeSH terms
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Adult
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Aged
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Cisapride
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Double-Blind Method
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Esophagogastric Junction / physiopathology
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Esophagus / drug effects
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Esophagus / physiopathology*
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Female
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Humans
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Male
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Middle Aged
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Mixed Connective Tissue Disease / drug therapy
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Mixed Connective Tissue Disease / physiopathology*
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Peristalsis / drug effects
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Piperidines / pharmacology*
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Pressure
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Scleroderma, Systemic / drug therapy
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Scleroderma, Systemic / physiopathology*
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Serotonin Antagonists / pharmacology*
Substances
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Piperidines
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Serotonin Antagonists
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Cisapride