Abstract
Four patients with chondrocalcinosis of the knees volunteered for joint lavage. Preliminary experiments indicated that disodium EDTA and magnesium ions were potent solubilizers of CPPD crystals. The procedure was a therapeutic failure in that insignificant amounts of CPPD were removed and all 4 subjects developed postlavage attacks of pseudogout. It is hypothesized that the acute attack of pseudogout is a result of crystal shedding and may be triggered by any factor that enhances CPPD solubility.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acute Disease
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Calcium Phosphates* / metabolism
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Chondrocalcinosis / drug therapy
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Chondrocalcinosis / etiology*
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Crystallization
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Diphosphates / metabolism
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Edetic Acid / adverse effects*
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Edetic Acid / therapeutic use
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Female
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Humans
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Knee Joint* / metabolism
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Magnesium Sulfate / adverse effects*
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Magnesium Sulfate / therapeutic use
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Male
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Middle Aged
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Solubility
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Synovial Fluid / analysis
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Therapeutic Irrigation / adverse effects
Substances
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Calcium Phosphates
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Diphosphates
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Magnesium Sulfate
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Edetic Acid