Natural regulatory T cells control the development of atherosclerosis in mice

Hafid Ait-Oufella; Benoît L Salomon; Stéphane Potteaux; Anna-Karin L Robertson; Pierre Gourdy; Joffrey Zoll; Régine Merval; Bruno Esposito; José L Cohen; Sylvain Fisson; Richard A Flavell; Göran K Hansson; David Klatzmann; Alain Tedgui; Ziad Mallat

doi:10.1038/nm1343

Natural regulatory T cells control the development of atherosclerosis in mice

Nat Med. 2006 Feb;12(2):178-80. doi: 10.1038/nm1343. Epub 2006 Feb 5.

Authors

Hafid Ait-Oufella¹, Benoît L Salomon, Stéphane Potteaux, Anna-Karin L Robertson, Pierre Gourdy, Joffrey Zoll, Régine Merval, Bruno Esposito, José L Cohen, Sylvain Fisson, Richard A Flavell, Göran K Hansson, David Klatzmann, Alain Tedgui, Ziad Mallat

Affiliation

¹ Institut National de la Santé et de la Recherche Médicale (Inserm), Unit 689, Centre de Recherche Cardiovasculaire Lariboisière, 41, Bd de la Chapelle, 75010 Paris, France.

PMID: 16462800
DOI: 10.1038/nm1343

Abstract

Atherosclerosis is an immunoinflammatory disease elicited by accumulation of lipids in the artery wall and leads to myocardial infarction and stroke. Here, we show that naturally arising CD4(+)CD25(+) regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens, are powerful inhibitors of atherosclerosis in several mouse models. These results provide new insights into the immunopathogenesis of atherosclerosis and could lead to new therapeutic approaches that involve immune modulation using regulatory T cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apolipoproteins E / deficiency
Apolipoproteins E / genetics
Atherosclerosis / etiology*
Atherosclerosis / immunology
Atherosclerosis / pathology
B7-1 Antigen / genetics
CD28 Antigens / genetics
DNA-Binding Proteins / deficiency
DNA-Binding Proteins / genetics
Female
Immunity, Innate
Mice
Mice, Inbred C57BL
Mice, Knockout
T-Lymphocytes, Regulatory / immunology*
T-Lymphocytes, Regulatory / pathology

Substances

Apolipoproteins E
B7-1 Antigen
CD28 Antigens
DNA-Binding Proteins
Rag2 protein, mouse