Abstract
IL-17 and its receptor are founding members of an emerging family of cytokines and receptors with many unique characteristics. IL-17 is produced primarily by T cells, particularly those of the memory compartment. In contrast, IL-17 receptor is ubiquitously expressed, making nearly all cells potential targets of IL-17. Although it has only limited homology to other cytokines, IL-17 exhibits proinflammatory properties similar to those of tumor necrosis factor-alpha, particularly with respect to induction of other inflammatory effectors. In addition, IL-17 synergizes potently with other cytokines, placing it in the center of the inflammatory network. Strikingly, IL-17 has been associated with several bone pathologies, most notably rheumatoid arthritis.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Animals
-
Arthritis, Rheumatoid / metabolism
-
Arthritis, Rheumatoid / physiopathology
-
Bone Diseases / metabolism
-
Bone Diseases / physiopathology
-
Bone Remodeling / physiology
-
Cytokines / biosynthesis
-
Cytokines / genetics
-
Gene Expression Regulation
-
Homeostasis
-
Humans
-
Immunity, Innate / physiology
-
Inflammation / metabolism*
-
Inflammation / physiopathology
-
Inflammation Mediators / metabolism
-
Interleukin-17 / chemistry
-
Interleukin-17 / physiology*
-
Mice
-
Mice, Knockout
-
Multigene Family
-
Osteoarthritis / metabolism
-
Osteoarthritis / physiopathology
-
Receptors, Interleukin / chemistry
-
Receptors, Interleukin / physiology*
-
Receptors, Interleukin-17
-
Signal Transduction
-
Vertebrates / physiology
Substances
-
Cytokines
-
IL17RA protein, human
-
Inflammation Mediators
-
Interleukin-17
-
Receptors, Interleukin
-
Receptors, Interleukin-17