Use of classification trees for association studies

Genet Epidemiol. 2000 Dec;19(4):323-32. doi: 10.1002/1098-2272(200012)19:4<323::AID-GEPI4>3.0.CO;2-5.

Abstract

We propose the use of classification trees for association studies. This approach is applied to a data set from Genetic Analysis Workshop 9 (GAW9), and our analysis precisely identified two disease alleles. Our purpose is to demonstrate the great potential of tree-based analyses for genetic studies, and discuss some issues that warrant further investigation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Family Health
  • Genetic Linkage
  • Genetic Markers
  • Genetic Predisposition to Disease*
  • Genome, Human
  • Humans
  • Models, Genetic*
  • Models, Statistical*
  • Molecular Epidemiology / methods*
  • Polymorphism, Genetic

Substances

  • Genetic Markers