Methotrexate effects in patients with rheumatoid arthritis with cardiovascular comorbidity

Lancet. 2000 May 6;355(9215):1616-7. doi: 10.1016/S0140-6736(00)02222-4.

Abstract

Methotrexate, an antirheumatic drug that may increase serum homocysteine, significantly increases mortality in patients with rheumatoid arthritis and cardiovascular comorbidity.

Publication types

  • Letter

MeSH terms

  • Adult
  • Aged
  • Antirheumatic Agents / adverse effects*
  • Antirheumatic Agents / therapeutic use
  • Arteriosclerosis / epidemiology*
  • Arteriosclerosis / mortality
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / epidemiology*
  • Arthritis, Rheumatoid / mortality
  • Comorbidity
  • Female
  • Humans
  • Male
  • Methotrexate / adverse effects*
  • Methotrexate / therapeutic use
  • Middle Aged
  • Retrospective Studies
  • Survival Analysis

Substances

  • Antirheumatic Agents
  • Methotrexate