Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases

P P Tak; N J Zvaifler; D R Green; G S Firestein

doi:10.1016/s0167-5699(99)01552-2

Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases

Immunol Today. 2000 Feb;21(2):78-82. doi: 10.1016/s0167-5699(99)01552-2.

Authors

P P Tak¹, N J Zvaifler, D R Green, G S Firestein

Affiliation

¹ Division of Clinical Immunology and Rheumatology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands. P.P.Tak@amc.uva.nl

PMID: 10652465
DOI: 10.1016/s0167-5699(99)01552-2

Abstract

Oxidative stress at sites of chronic inflammation can cause permanent genetic changes. The development of mutations in the p53 tumor suppressor gene and other key regulatory genes could help convert inflammation into chronic disease in rheumatoid arthritis and other inflammatory disorders.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Arthritis, Rheumatoid / genetics
Arthritis, Rheumatoid / immunology
Arthritis, Rheumatoid / metabolism*
Bursa, Synovial / cytology
Bursa, Synovial / metabolism
Genes, p53 / drug effects
Genes, p53 / genetics
Humans
Mutation
Oxidative Stress / physiology*
Reactive Oxygen Species / metabolism
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / metabolism*

Substances

Reactive Oxygen Species
Tumor Suppressor Protein p53