Abstract
Oxidative stress at sites of chronic inflammation can cause permanent genetic changes. The development of mutations in the p53 tumor suppressor gene and other key regulatory genes could help convert inflammation into chronic disease in rheumatoid arthritis and other inflammatory disorders.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Arthritis, Rheumatoid / genetics
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Arthritis, Rheumatoid / immunology
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Arthritis, Rheumatoid / metabolism*
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Bursa, Synovial / cytology
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Bursa, Synovial / metabolism
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Genes, p53 / drug effects
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Genes, p53 / genetics
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Humans
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Mutation
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Oxidative Stress / physiology*
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Reactive Oxygen Species / metabolism
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Tumor Suppressor Protein p53 / genetics
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Tumor Suppressor Protein p53 / metabolism*
Substances
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Reactive Oxygen Species
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Tumor Suppressor Protein p53