Intravenous immunoglobulin compared with cyclophosphamide for proliferative lupus nephritis

Lancet. 1999 Aug 14;354(9178):569-70. doi: 10.1016/S0140-6736(99)01575-5.

Abstract

Among 14 randomised patients with proliferative lupus nephritis, monthly intravenous immunoglobulin maintained remission over 18 months, similar to standard intravenous cyclophosphamide treatment. Pulsed immunoglobulin may be a useful alternative therapy in lupus nephritis.

Publication types

  • Clinical Trial
  • Comparative Study
  • Letter
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Cyclophosphamide / therapeutic use*
  • Drug Administration Schedule
  • Female
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use*
  • Immunosuppressive Agents / therapeutic use*
  • Injections, Intravenous
  • Lupus Erythematosus, Systemic / drug therapy
  • Lupus Nephritis / drug therapy*
  • Male
  • Middle Aged
  • Pilot Projects
  • Treatment Outcome

Substances

  • Immunoglobulins, Intravenous
  • Immunosuppressive Agents
  • Cyclophosphamide