Abstract
The development of acute graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation is mediated by alloreactive donor T cells infused with the bone marrow inoculum. This review discusses the role and significance of host-specific cytotoxic and lymphokine-secreting donor T cells for the prediction and generation of acute GVHD.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acute Disease
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Bone Marrow Transplantation / immunology*
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Graft vs Host Disease / immunology*
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Humans
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Lymphokines / metabolism
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T-Lymphocytes, Cytotoxic / immunology*
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T-Lymphocytes, Helper-Inducer / immunology*
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T-Lymphocytes, Helper-Inducer / metabolism
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T-Lymphocytes, Helper-Inducer / transplantation
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Transplantation, Homologous