Foot involvement in systemic sclerosis: A longitudinal study of 100 patients*,**
Section snippets
Patients and methods
We examined the clinical records of 100 SSc patients in whom hand and foot radiographs were available in the archives of our clinic in December 2000. All the patients had been admitted to our unit between 1979 and 2000. The baseline epidemiologic and clinical characteristics of this cohort of patients were not different from 223 other SSc patients admitted from January 1, 1965, to June 30, 1994 (our whole series consisting of 323 subjects on June 1994) nor from those of the 183 admitted during
Results
Ninety-six SSc patients satisfied the ACR criteria for the classification of SSc. In the remaining 4 cases, the diagnosis was established by the coexistence of anticentromere antibodies (ACA), sclerodactily, and esophageal involvement.
There were 74 cases with limited scleroderma (lcSSc), and 26 cases with diffuse scleroderma (dcSSc). Ninety-seven were ANA positive, 29 (of 100) were ACA positive, and 52 (of 85; 61%) were anti-Scl 70 positive. RF at a low titer (median, 1:80) was detected in 35
Discussion
Our study has several limitations, including its retrospective nature and the fact that patients had a long disease duration at presentation. Therefore, our conclusions apply only to long-surviving SSc patients. Two other points deserve to be addressed. The low prevalence of arthralgia may be a consequence of limiting our search to the feet and hands. The high prevalence of anti DNA-topoisomerase is a well-established feature of our series 13, 14 and may relate to unestablished ethnic or
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Cited by (55)
Patients’ perspectives on systemic sclerosis-related Raynaud's phenomenon in the feet: A qualitative study from the OMERACT Foot and Ankle Working Group
2024, Seminars in Arthritis and RheumatismImpact of foot functionality in patients with systemic sclerosis: Cross-sectional study
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2022, Egyptian RheumatologistCitation Excerpt :In this study bone erosions were found in 36% of patients compared to other studies [15,16] that showed 40% of their patients had bone erosions. Avouac et al [22] and La Montagna et al [3], found that the prevalence of articular erosion in SSc had been estimated between 5 and 40%, however, Iagnocco et al [23], found that bone erosions were irrelevant abnormalities, while cortical irregularities may represent an interesting finding to be considered in the evaluation of SSc patients. The incidence of synovitis in this work was higher in diffuse than limited SSc which is in agreement with Avouac et al [22] who found that the frequency of synovitis was significantly higher in patients with the diffuse compared to the limited cutaneous subtype.
Osteoarticular manifestations of systemic sclerosis: A systematic review of the literature
2020, Revista Colombiana de Reumatologia
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Giovanni La Montagna, MD: Assistant Professor of Rheumatology, Antonietta Baruffo, MD: Clinical Assistant in Rheumatology, Rosella Tirri, MD: Investigator in Rheumatology, Giovanni Buono, MD: Fellow in Rheumatology, Gabriele Valentini, MD: Professor of Rheumatology and Chief of Rheumatology Unit; Dipartimento di Internistica Clinica e Sperimentale “F. Magrassi”–Seconda Università degli Studi di Napoli, Naples Italy.
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Address reprint requests to Dr. G. La Montagna, Divisione di Reumatologia, Seconda Università degli Studi di Napoli, Via S. Pansini, 5-80131 Napoli, Italy. E-mail: [email protected]