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Microchimerism: Friend or foe?

Nature Medicine volume 4, pages 386–388 (1998)Cite this article

Non-self fetal cells in women with scleroderma suggest a mechanism similar to allogeneic graft-versus-host disease in autoimmunity.

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References

  1. Nelson, J.L. et al. Microchimerism and HLA-compatible relationships of pregnancy in scleroderma. Lancet 351, 559–562 (1998).

    Article  CAS  Google Scholar 

  2. Artlett, C.M., Smith, J.B. & Jimenez, S.A. Identification of fetal cells in the active lesions of skin biopsies of women with systemic sclerosis. Arthritis Rheum. 40, S218 (1997).

    Google Scholar 

  3. Gratwohl, A. et al. Sjogren-type syndrome after allogeneic bone marrow transplantation. Ann. Int. Med. 87, 703–706 (1977)

    Article  CAS  Google Scholar 

  4. Lawley, T. et al. Scleroderma, Sjogren-type syndrome and chronic graft-versus-host disease. Ann. Int. Med. 87, 707–709 (1977).

    Article  CAS  Google Scholar 

  5. Artlett, C.M., Welsh, K.I., Black, C.M. & Jimenez, S.A. Fetal-maternal HLA compatibilty confers susceptibility to systemic sclerosis. Immunogenetics 47, 17–22 (1 998).

    Article  CAS  Google Scholar 

  6. Orlin, J.B. & Ellis, M.H. Transfusion associated graft-versus-host disease. Curr. Opin. Hematol. 4, 442–448 (1997)

    Article  CAS  Google Scholar 

  7. Welsh, K.I. Scleroderma: chimerism, the blind man and the scientist. Lancet 351, 540–541 (1998).

    Article  CAS  Google Scholar 

  8. Alamas, S.P., Wigley, F.M. & White, B. Is microen-graftment with maternal or fetal cells a risk factor for the development of systemic sclerosis? Arthritis Rheum. 40, S199 (1997).

    Article  Google Scholar 

  9. Sykes, M. et al. Induction of high levels of allogeneic hematopoietic reconstitution and donor specific tolerance without myelosuppressive conditioning. Nature Med. 3, 783–787 (1997).

    Article  CAS  Google Scholar 

  10. Tyndall, A. & Cratwohl, A. Blood and bone marrow stem cell transplants in autoimmune disease: A consensus report written on behalf of the European League Against Rheumatism (EULAR) and the European Group for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant 19, 643–645 (1997).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Rheumatology, University of Basel, CH-4031, Basel, Switzerland

    Alan Tyndall

  2. Division of Hematology, University of Basel, CH-4031, Basel, Switzerland

    Alois Gratwohl

Authors
  1. Alan Tyndall
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  2. Alois Gratwohl
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Tyndall, A., Gratwohl, A. Microchimerism: Friend or foe?. Nat Med 4, 386–388 (1998). https://doi.org/10.1038/nm0498-386

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