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The 3′ untranslated region of messenger RNA: A molecular ‘hotspot’ for pathology?

Nature Medicine volume 6, pages 637–641 (2000)Cite this article

Abstract

The role of the 3′ untranslated region in posttranscriptional regulation of mRNA expression is being elucidated. Here we describe diseases arising from anomalies in this region, that affect the expression of one or more genes.

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Figure 1: Multiple functions for mRNA 3′ UTRs.
Figure 2: Hypothetical model of myotonic dystrophy.
Figure 3: Model of α-globin mRNA stabilization.

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Article 20 October 2020

Gregory J. Goodall & Vihandha O. Wickramasinghe

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Acknowledgements

The authors thank S. Antonarakis, F. Negro and J. Schwaller for critical reading of the manuscript.

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  1. Béatrice Conne

    Present address: Department of Pathology, CMU 1211, Geneva, 4, Switzerland

Authors and Affiliations

  1. Department of MorphologyFaculty of Medicine University of Geneva CMU, 1211 Geneva 4, Switzerland

    Béatrice Conne, André Stutz & Jean-Dominique Vassalli

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Correspondence to Béatrice Conne.

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Conne, B., Stutz, A. & Vassalli, JD. The 3′ untranslated region of messenger RNA: A molecular ‘hotspot’ for pathology?. Nat Med 6, 637–641 (2000). https://doi.org/10.1038/76211

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