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Osteoarthritis

The zinc link

Increased influx of zinc into chondrocytes — the cells that make up cartilage — has been found to activate matrix-degrading enzymes that cause the destruction of cartilage in osteoarthritis.

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Figure 1: The downward spiral of osteoarthritis.

References

  1. Velnar, T., Bailey, T. & Smrkolj, V. J. Int. Med. Res. 37, 1528–1542 (2009).

    Article  CAS  Google Scholar 

  2. Scanzello, C. R., Plaas, A. & Crow, M. K. Curr. Opin. Rheumatol. 20, 565–572 (2008).

    Article  CAS  Google Scholar 

  3. Kim, J.-H. et al. Cell 156, 730–743 (2014).

    Article  CAS  Google Scholar 

  4. Lansdown, A. B. G., Mirastschijski, U., Stubbs, N., Scanlon, E. & Ågren, M. S. Wound Repair Regen. 15, 2–16 (2007).

    Article  Google Scholar 

  5. Xue, M., Le, N. T. V. & Jackson, C. J. Expert Opin. Ther. Targets 10, 143–155 (2006).

    Article  CAS  Google Scholar 

  6. Song, J. et al. J. Biomed. Sci. 20, 31 (2013).

    Article  CAS  Google Scholar 

  7. Findlay, D. M. in Principles of Osteoarthritis: Its Definition, Character, Derivation and Modality-Related Recognition (ed. Rothschild, B. M.) Ch. 7, 139–154 (InTech, 2012).

    Google Scholar 

  8. Liu-Bryan, R. Curr. Rheumatol. Rep. 15, 323 (2013).

    Article  Google Scholar 

  9. Rai, M. F. et al. Arthritis Rheum. 64, 2300–2310 (2012).

    Article  Google Scholar 

  10. Lewis, J. S. Jr et al. Arthritis Rheum. 65, 660–670 (2013).

    Article  CAS  Google Scholar 

  11. Gege, C. et al. J. Med. Chem. 55, 709–716 (2012).

    Article  CAS  Google Scholar 

  12. Lee, J. H., Fitzgerald, J. B., DiMicco, M. A. & Grodzinsky, A. J. Arthritis Rheum. 52, 2386–2395 (2005).

    Article  CAS  Google Scholar 

  13. de Isla, N. G., Yang, J. W., Huselstein, C., Muller, S. & Stoltz, J. F. Biorheology 43, 595–601 (2006).

    CAS  PubMed  Google Scholar 

  14. van den Berg, W. B., Joosten, L. A. B. & van de Loo, F. A. J. Clin. Exp. Rheumatol. 17 (Suppl. 18), 0105–0114 (1999).

    Google Scholar 

  15. Gao, J., Zhao, N., Knutson, M. D. & Enns, C. A. J. Biol. Chem. 283, 21462–21468 (2008).

    Article  CAS  Google Scholar 

  16. Kraus, V. B. in Rheumatology (eds Hochberg, M. C., Silman, A. J., Smolen, J. S., Weinblatt, M. E. & Weisman, M. H.) Ch. 179 (Mosby, in the press).

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Correspondence to Virginia Byers Kraus.

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Kraus, V. The zinc link. Nature 507, 441–442 (2014). https://doi.org/10.1038/507441a

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