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Proteolysis, proteasomes and antigen presentation

Nature volume 357, pages 375–379 (1992)Cite this article

Abstract

Proteins presented to the immune system must first be cleaved to small peptides by intracellular proteinases. Proteasomes are proteolytic complexes that degrade cytosolic and nuclear proteins. These particles have been implicated in ATP-ubiquitin-dependent proteolysis and in the processing of intracellular antigens for cytolytic immune responses.

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Authors and Affiliations

  1. Department of Cellular and Molecular Physiology, Harvard Medical School,

    Alfred L. Goldberg

  2. Department of Pathology, Harvard Medical School and Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, USA

    Kenneth L. Rock

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  1. Alfred L. Goldberg
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  2. Kenneth L. Rock
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Goldberg, A., Rock, K. Proteolysis, proteasomes and antigen presentation. Nature 357, 375–379 (1992). https://doi.org/10.1038/357375a0

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