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How the immune system puts the brain to sleep

Abstract

Tumor necrosis factor, an essential mediator of inflammation, inhibits degradation of the molecular switch RGS7 and may lead to the neurological changes that occur during inflammation (page 913).

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Figure 1: TNF promotes signaling through GαS proteins.

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Straub, R., Männel, D. How the immune system puts the brain to sleep. Nat Med 5, 877–879 (1999). https://doi.org/10.1038/11315

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