Abstract
Tumor necrosis factor, an essential mediator of inflammation, inhibits degradation of the molecular switch RGS7 and may lead to the neurological changes that occur during inflammation (page 913).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Benzing, T. et al. Upregulation of RGS7 may contribute to tumor necrosis factor-induced changes in central nervous function. Nature Med. 5, 913–918 (1999).
Gilman, A.G. Nobel Lecture. G proteins and regulation of adenylyl cyclase. Biosci. Rep. 15, 65–97 ( 1995).
Luttrell, L.M. et al. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 283, 655 –661 (1999).
Berman, D.M. & Gilman, A.G. Mammalian RGS proteins: barbarians at the gate. J. Biol. Chem. 273, 1269– 1272 (1998).
Kehrl, J.H. Heterotrimeric G protein signaling: roles in immune function and fine-tuning by RGS proteins. Immunity 8, 1– 10 (1998).
Hu, X.X., Goldmuntz, E.A. & Brosnan, C.F. The effect of norepinephrine on endotoxin-mediated macrophage activation. J. Neuroimmunol. 31, 35–42 (1991).
Severn, A., Rapson, N.T., Hunter, C.A. & Liew, F.Y. Regulation of tumor necrosis factor production by adrenaline and beta- adrenergic agonists. J. Immunol. 148, 3441– 3445 (1992).
Panetta, R., Guo, Y., Magder, S. & Greenwood, M.T. Regulators of G-protein signaling (RGS) 1 and 16 are induced in response to bacterial lipopolysaccharide and stimulate c-fos promoter expression. Biochem. Biophys. Res. Commun. 259, 550–556 (1999).
Besedovsky, H.O. & Del Rey, A. Immune-neuro-endocrine interactions. Endocr. Rev. 17, 64– 102 (1996).
Straub,R.H., Westermann,J., Schölmerich, J. & Falk,W. Dialogue between CNS and immune system in lymphoid organs. Immunol. Today 19, 409–413 ( 1998).
Bluthe,R.M. et al. Synergy between tumor necrosis factor alpha and interleukin-1 in the induction of sickness behavior in mice. Psychoneuroendocrinology 19, 197–207 ( 1994).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Straub, R., Männel, D. How the immune system puts the brain to sleep. Nat Med 5, 877–879 (1999). https://doi.org/10.1038/11315
Issue Date:
DOI: https://doi.org/10.1038/11315