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Increased Prevalence of Autoantibodies in Celiac Disease

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Abstract

Several features suggest an immune mechanismoperates in celiac disease. Information on theautoantibody repertoire in this condition is lacking.The purpose of the study was to investigate thereactivity of celiac patients sera to various autoantigenswidely distributed in the human intestine. Seventychildren, celiacs and controls, were evaluated for serumautoantibodies using ELISA and immunofluorescence. Celiac patients had increased prevalence ofserum anti-single-stranded DNA (14%),anti-double-stranded DNA (23%), anticardiolipin (14%),and anti-endomysial autoantibodies (63%). The relevanceof this finding on the extraintestinal manifestations of celiacdisease or the coexistence of autoimmune conditions andceliac disease remains to be determined.

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Authors
  1. A. Lerner
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  2. M. Blank
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  3. N. Lahat
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  4. Y. Shoenfeld
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Lerner, A., Blank, M., Lahat, N. et al. Increased Prevalence of Autoantibodies in Celiac Disease. Dig Dis Sci 43, 723–726 (1998). https://doi.org/10.1023/A:1018801711413

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