The Selectins and their Ligands: Adhesion Molecules of the Vasculature
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The roles of P- and E-selectins and P-selectin glycoprotein ligand-1 in primary and metastatic mouse melanomas
2011, Journal of Dermatological ScienceCitation Excerpt :Leukocytes first tether and roll on vascular endothelial cells before they are activated to adhere firmly and subsequently emigrate into the extravascular space. The selectin family cooperates to support leukocyte tethering and rolling along inflamed vascular walls and consists of three cell-surface molecules expressed by leukocytes (L-selectin) [7], vascular endothelium (E- and P-selectins) [7], and platelets (P-selectin) [7]. P-selectin is rapidly expressed on the endothelial cell surface upon degranulation of Weibel-Palade bodies, and its synthesis can be further increased by cytokines.
Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction
2010, American Journal of PathologyLow zone tolerance requires ICAM-1 expression to limit contact hypersensitivity elicitation
2009, Journal of Investigative DermatologyCitation Excerpt :L-selectin is constitutively expressed by most leukocytes, whereas P-selectin and E-selectin are expressed by activated endothelial cells (Tedder et al., 1999). By interacting with its ligand, N-glycan-linked 6-sulfo sialyl Lewis X, L-selectin mediates leukocyte capture and rolling on the endothelium (Tedder et al., 1999; Mitoma et al., 2007). L-selectin-deficient (L-selectin−/-) mice consistently exhibit decreased CHS responses (Staite et al., 1996; Steeber et al., 1999).
Cell adhesion molecules, the extracellular matrix and oral squamous carcinoma
2007, International Journal of Oral and Maxillofacial SurgeryCitation Excerpt :In view of this, loss of α-DG may be a useful prognostic indicator. Selectins (Fig. 1) are a group of single-chain transmembrane proteins found on platelets, leukocytes, lymphocytes and endothelial cells103. Each selectin is composed of a tandem arrangement of discrete protein domains.
Phase-dependent roles of E-selectin during chronic contact hypersensitivity responses
2007, American Journal of PathologyCharacteristics of two CD75-related cell-surface expressed antigens of human lymphocytes
2007, Molecular Immunology