The Selectins and their Ligands: Adhesion Molecules of the Vasculature

https://doi.org/10.1016/S1569-2558(08)60044-2Get rights and content

Publisher Summary

Leukocyte rolling and adhesion to endothelium are dynamic processes that involve multiple adhesion receptors and the active participation of the cells involved. Current data obtained from in vitro and in vivo assays, gene-targeted mice, and antibody-blocking studies demonstrate that leukocyte rolling is likely to result from cumulative additive interactions with several molecules contributing in both specialized and redundant ways. Selectin expression is critical for capturing leukocytes from the streaming blood, while the synergistic action of the selectins and some integrins contribute to selectin-mediated rolling. Regulatory mechanisms that control these events include the rapid mobilization of presynthesized P-selectin to the cell surface, increased rates of selectin protein synthesis, induced transcription of the E-selectin gene, changes in cycling of E- and P-selectin from the cell surface to intracellular compartments, rapid shedding of L-selectin from the cell surface, activation-induced changes in L-selectin avidity for ligands, and alterations in cytoskeletal associations. The control of selectin ligand function through induction of their synthesis, differential glycosylation, and release from the cell surface are also important regulatory events. The differential expression and function of the selectins by various leukocyte subclasses and diverse beds of vascular endothelium allows for considerable specificity in leukocyte migration into tissues at sites of inflammation, wound healing, and immune responses.

References (326)

  • T. Collins et al.

    Structure and chromosomal location of the gene for endothelial leukocyte adhesion molecule 1.

    J Biol. Chem.

    (1991)
  • C.S. Crovello et al.

    Histidine phosphorylation of P-selectin upon stimulation of human platelets: a novel pathway for activation-dependent signal transduction

    Cell

    (1995)
  • L.G. De Luca et al.

    CAMP and TNF competitively regulate transcriptional activation through and nuclear factor binding to the CRE-ATF element of the E-selectin promoter

    J. Biol. Chem.

    (1994)
  • DonnellyS.C. et al.

    Altered levels of soluble L-selectin adhesion receptor in plasma is correlated with development of the adult respiratory distress syndrome (ARDS) in at-risk patient groups

    Lancet

    (1994)
  • DoreM. et al.

    P-selectin mediates spontaneous leukocyte rolling in vivo

    Blood

    (1993)
  • N.A. Essani et al.

    Differential induction of mRNA for ICAM-1 and selectins in hepatocytes, Kupffer cells, and endothelial cells during endotoxemia

    Biochem. Biophys. Res. Commun.

    (1995)
  • FeehanC. et al.

    Shedding of the lymphocyte L-selectin adhesion molecule is inhibited by a hydroxamic acid-based protease inhibitor

    J. Biol. Chem.

    (1996)
  • T. Feizi

    Oligosaccharides that mediate mammalian cell-cell adhesion

    Curr. Opin. Struct. Biol.

    (1993)
  • L. Fina et al.

    Expression of CD34 gene in vascular endothelial cells

    Blood

    (1990)
  • P.S. Frenette et al.

    Susceptibility to infection and altered hematopoiesis in mice deficient in both

    P- and E-selectins. Cell

    (1996)
  • FujimotoT. et al.

    The cytoplasmic domain of P-selectin is phosphorylatedon serine and threonine residues

    Blood

    (1993)
  • J.P. Gaboury et al.

    Reductions in physiologic shear rates lead to CDll/CD18-dependent, selectin-independent leukocyte rolling in vivo

    Blood

    (1994)
  • R.M. Gibson et al.

    Lectin and epidermal growth factor domains of P-selectin at physiological density are the recognition unit for leukocyte binding

    Blood

    (1995)
  • S.E. Goelz et al.

    ELFT: A gene that directs the expression of an. ELAM-1 ligand

    Cell

    (1990)
  • P.J. Green et al.

    High affinity binding of the leukocyte adhesion molecule L-selectin to 3'-sulfated-Lea and -Lex oligosaccharides and the predominance of sulphate in this interaction demonstrated by binding studies with a series of. lipid-linked oligosaccharides

    Biochem. Biophys. Res. Commun.

    (1992)
  • D.A. Guyer et al.

    P-selectin glycoprotein ligand-1 (PSGL-1) is a ligand for L-selectin in neutrophil aggregation

    Blood

    (1996)
  • HandaK. et al.

    Selectin GMP-140 (CD62; PADGEM) binds to siaIosyI-Lea and sia!osyI-Lex, and sulfated glycans modulate this binding

    Biochem. Biophys. Res. Commun.

    (1991)
  • B. Haribabu et al.

    Chemoattractant receptor-induced phosphorylation of

    L-selectin. J. Biol. Chem.

    (1997)
  • R. Hattori et al.

    Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140

    J. Biol. Chem.

    (1989)
  • P. Hensley et al.

    The soluble form of E-selectin is an asymmetric monomer. Expression, purification, and characterization of the recombinant protein

    J. Biol. Chem.

    (1994)
  • D. Hoke et al.

    Selective modulation of the expression of L-selectin ligands by an immune response

    Current Biol.

    (1995)
  • S.-C. Hsu-Lin et al.

    A platelet membrane protein expressed during platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin-activated platelets

    J. Biol. Chem.

    (1984)
  • O. Abbassi et al.

    E-selectin supports neutrophil rolling in vitro under conditions of flow

    J. Clin. Invest.

    (1993)
  • O. Abbassi et al.

    Canine neutrophil margination mediated by lectin adhesion molecule-1 in vitro

    J. Immunol.

    (1991)
  • S. Aigner et al.

    Heat-stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet

    P-selectin. Int. Immunol.

    (1995)
  • T. Akahori et al.

    Role of a sialyl Lewisx-like epitope selectively expressed on vascular endothelial cells in local skin inflammation of the rat

    J. Immunol.

    (1997)
  • J.R. Allport et al.

    L-selectin shedding does not regulate human neutrophil attachment, rolling or transmigration across human vascular endothelium in vitro

    J. Immunol.

    (1997)
  • R. Alon et al.

    Interactions through L-selectin between leukocytes and adherent leukocytes nucleate rolling adhesions on selectins and VCAM-1 in shear flow

    J. Cell Biol.

    (1996)
  • R. Alon et al.

    Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow

    Nature

    (1995)
  • R. Alon et al.

    The integrinVLA-4 supports tethering and rolling in flow on VCAM-1

    J. Cell Biol.

    (1995)
  • D. Asa et al.

    The P-selectin glycoprotein ligand functions as a common human leukocyte ligand for

    P- and E-selectins. J. Biol. Chem.

    (1995)
  • H. Asako et al.

    Role of HI receptors and P-selectin in histamine-induced leukocyte rolling and adhesion in postcapillary venules

    J. Clin. Invest.

    (1994)
  • AthertonA. et al.

    Quantitative investigation of the adhesiveness of circulating polymorphonuclear leukocytes to blood vessel walls

    J. Physiol.

    (1972)
  • R.F. Bargatze et al.

    Neutrophils roll on adherent neutrophils bound to cytokine-induced endothelial cells via L-selectin on the rolling cells

    J. Exp. Med.

    (1994)
  • S. Baumhueter et al.

    Binding of L-selectin to the vascular sialomucin CD34

    Science

    (1993)
  • E.L. Berg et al.

    L-selectin-mediated lymphocyte rolling on

    MAdCAM-1. Nature

    (1993)
  • E.L. Berg et al.

    The human peripheral lymphnode vascular addressin is a ligand for LECAM-1, the peripheral lymph node homing receptor

    J. Cell. Biol.

    (1991)
  • C. Berg et al.

    Cc4p7 integrin mediates lymphocyte binding to the mucosal vascular addressin

    MAdCAM-1. Cell

    (1993)
  • C.L. Berman et al.

    A platelet alpha granule membrane protein that is associated with the plasma membrane after activation

    J. Clin. Invest.

    (1986)
  • M.P. Bevilacqua et al.

    Identification of an inducible endothelial-leukocyte adhesion molecule

    Proc Natl. Acad. Sci. USA

    (1987)
  • Cited by (37)

    • The roles of P- and E-selectins and P-selectin glycoprotein ligand-1 in primary and metastatic mouse melanomas

      2011, Journal of Dermatological Science
      Citation Excerpt :

      Leukocytes first tether and roll on vascular endothelial cells before they are activated to adhere firmly and subsequently emigrate into the extravascular space. The selectin family cooperates to support leukocyte tethering and rolling along inflamed vascular walls and consists of three cell-surface molecules expressed by leukocytes (L-selectin) [7], vascular endothelium (E- and P-selectins) [7], and platelets (P-selectin) [7]. P-selectin is rapidly expressed on the endothelial cell surface upon degranulation of Weibel-Palade bodies, and its synthesis can be further increased by cytokines.

    • Low zone tolerance requires ICAM-1 expression to limit contact hypersensitivity elicitation

      2009, Journal of Investigative Dermatology
      Citation Excerpt :

      L-selectin is constitutively expressed by most leukocytes, whereas P-selectin and E-selectin are expressed by activated endothelial cells (Tedder et al., 1999). By interacting with its ligand, N-glycan-linked 6-sulfo sialyl Lewis X, L-selectin mediates leukocyte capture and rolling on the endothelium (Tedder et al., 1999; Mitoma et al., 2007). L-selectin-deficient (L-selectin−/-) mice consistently exhibit decreased CHS responses (Staite et al., 1996; Steeber et al., 1999).

    • Cell adhesion molecules, the extracellular matrix and oral squamous carcinoma

      2007, International Journal of Oral and Maxillofacial Surgery
      Citation Excerpt :

      In view of this, loss of α-DG may be a useful prognostic indicator. Selectins (Fig. 1) are a group of single-chain transmembrane proteins found on platelets, leukocytes, lymphocytes and endothelial cells103. Each selectin is composed of a tandem arrangement of discrete protein domains.

    View all citing articles on Scopus
    View full text