The Journal of Steroid Biochemistry and Molecular Biology
Androgen stimulation of lacrimal gland function in mouse models of Sjögren's syndrome
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Cited by (97)
Sexual health in women with Sjogren's syndrome: A review
2023, European Journal of Obstetrics and Gynecology and Reproductive BiologyTFOS DEWS II Sex, Gender, and Hormones Report
2017, Ocular SurfaceCitation Excerpt :Acinar and/or ductal epithelial cells, in turn, are thought to be the primary cells involved in the initiation and perpetuation of autoimmune reactivity in Sjögren syndrome [512]. This androgen-epithelial cell interaction may then induce the altered activity of specific genes and proteins in lacrimal tissue (e.g. cytokines, proto-oncogenes and apoptotic factors), leading to the reduction of immunopathological lesions and an improvement in glandular function [348,358,374,375,377,384]. In contrast to the above, some investigators have proposed that androgen insufficiency causes an autoimmune process in the lacrimal gland, leading to inflammation, a Sjögren syndrome-like pathology and aqueous tear deficiency [361,362,513,514].
Ocular Mucosal Immunity
2015, Mucosal Immunology: Fourth EditionPotentially pathogenic immune cells and networks in apparently healthy lacrimal glands
2015, Ocular SurfaceCitation Excerpt :The importance of ongoing, constitutive peripheral immunoregulatory mechanisms is emphasized by the identification of lacrimal epithelial cell internal vesicle trafficking pathways that may constitutively release autoantigens to the lacrimal gland's stromal spaces.29 Androgen therapy has proven highly beneficial in some murine models of inflammatory lacrimal gland diseases,30 and a preliminary case review study has suggested that androgen supplementation of estrogen-progestin replacement therapy ameliorates signs and symptoms in women with severe dry eye disease.31 Studies have found a number of intriguing clues into how the lacrimal epithelia function as a nexus between hormonal status and local immunological activity; nonetheless, this nexus has remained largely a black box, slow to yield insights into its inner workings.
Sjögren's Syndrome
2013, Women and Health