Declining gonadal function in elderly men
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Cited by (171)
Possible effects of low testosterone levels on olfactory function in males
2021, Brazilian Journal of OtorhinolaryngologyHormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications
2021, Mayo Clinic ProceedingsCitation Excerpt :The anabolic effect of T is reduced during aging because of a gradual and consistent decline in circulating T that begins around the third to fourth decade of life in men,28,29 also known as andropause. Approximately 40% to 50% of men over the age of 80 have T levels below that of normal healthy young individuals.28,30 By the third decade, both men and premenopausal women experience a decline in DHEA and DHEA-S,31 which can serve as precursors for the production of androgenic hormones such as T.32 The decline in total and free T levels in men occurs at a rate of approximately 1% and 2% per year, respectively (Figure 1A).33,34
Steroid secretion in healthy aging
2019, PsychoneuroendocrinologyCitation Excerpt :In support of this assumption, stimulation tests with exogenous GnRH show no difference in the subsequent LH secretion in young compared to old men, reflecting similar pituitary function (Kaufman and Vermeulen, 1997). However, it has been suggested that the paradoxical findings of an age-related decrease in LH pulse amplitudes but elevated LH levels in older men are caused by increased plasma half-life of LH and increased LH pulse frequency (Iranmanesh et al., 2010; Kaufman and Vermeulen, 1997). With regard to the causal factors leading to a decline in DHEA, the aforementioned morphological changes in the zona reticularis cause an up to 70% reduction of circulating DHEA levels in aging men (Ferrari and Mantero, 2005; Walther and Ehlert, 2015).
Age-related mechanical strength evolution of trabecular bone under fatigue damage for both genders: Fracture risk evaluation
2018, Journal of the Mechanical Behavior of Biomedical MaterialsNew Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men
2018, Advances in Clinical ChemistryCitation Excerpt :Limitations to these studies include heterogeneous definitions, demographic and clinical factors including T cutoff values, inclusion of symptoms, ethnicity, population type, and exclusion based on comorbidities. In summary, the overall prevalence of male hypogonadism appears to vary from 2% to 12% and increases with age [92,100,103,107]. Production of T is primarily dependent on the HPG axis [93].