The role of tumor necrosis factor-α in the pathogenesis of anorexia and bulimia nervosa, cancer cachexia and obesity
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2023, PsychoneuroendocrinologyA systematic review of in vitro cytokine production in eating disorders
2019, Molecular and Cellular EndocrinologyCitation Excerpt :For example, cytokines directly impact appetite and feeding regulation through interactions with orexigenic and anorexigenic neurohormones, neuropeptides, and neurotransmitters (e.g., Amaral et al., 2006; Romanatto et al., 2007; Wang et al., 2006). They also exert their effects on the central nervous system and on neurons in the hypothalamus, the ‘feeding centre’ of the brain (Holden and Pakula, 1996; Plata-Salaman et al., 1996). Cytokines have also been shown to play a mediatory role in the complex relationship between the immune and neuroendocrine systems.
Ovotransferrin enhances intestinal immune response in cyclophosphamide-induced immunosuppressed mice
2018, International Journal of Biological MacromoleculesCitation Excerpt :Intestine is one of an important functional organ in our body, nutritional proteins in food which are digested into peptides and absorbed by the intestine to exert its effect on the intestinal APCs and promote intestinal secretion of hormones, which resulting in immune regulation and mucosal barrier function, thus the intestinal APCs play an important role in the intestinal immune response [19,20]. DCs are the most APCs and important for intestinal immune function, numerous studies have shown that DCs distributed in the intestinal mucosa system while other APCs for the phagocytosis and presentation of foreign materials (antigens), the transmission of information to immune cells, thereby activating innate immune system and regulating the immune function [21,22]. DCs are also involved in the pathogenesis of several diseases caused by immune dysfunction, such as chronic inflammation and autoimmunity.
Can neuroimmune mechanisms explain the link between ultraviolet light (UV) exposure and addictive behavior?
2018, Brain, Behavior, and ImmunityCitation Excerpt :Taken together, this suggests that the rewarding, and possibly addictive, effects of some drugs require stimulation not only of neuronal but also of immune-like cell functioning (Coller and Hutchinson, 2012; Hutchinson and Watkins, 2014). Inflammation also plays a role in the onset and maintenance of binge eating behavior, which is now listed in the diagnostics for addiction disorders (Corcos et al., 2003; Holden and Pakula, 1996). Binge eating and excessive consumption of certain foods can produce behaviors and changes in the brain that resemble an addiction-like state, involving adaptations to both the dopamine and opioid systems similar to that seen with drugs of abuse (Bello and Hajnal, 2010; Corwin et al., 2011).