Cat peripheral nerve regeneration across 50 mm gap repaired with a novel nerve guide composed of freeze-dried alginate gel
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2024, International Journal of Biological MacromoleculesTherapeutic polymer gel system in neural tissue engineering
2023, Biomaterials for Neural Tissue EngineeringTissue-engineered nerve guides with mesenchymal stem cells in the facial nerve regeneration
2021, Neurochemistry InternationalCitation Excerpt :Therefore, a long nerve gap experimental model is necessary to examine facial nerve regeneration using biomaterials as alternatives to nerve autografting for peripheral nerve gaps. Suzuki et al. reported regeneration of a 50-mm gap cat sciatic nerve using an artificial nerve guide, composed of biodegradable freeze-dried alginate gel covered with a polyglycolic acid mesh (Suzuki et al., 1999). Matsumoto et al. demonstrated the regeneration of an 80-mm peroneal nerve gap using a PGA–collagen tube filled with laminin-coated collagen fibers in dogs (Matsumoto et al., 2000).
Alginate and alginate composites for biomedical applications
2021, Asian Journal of Pharmaceutical SciencesCavernous Branched Nerve Regeneration Using Non-Tubular Artificial Nerve Sheets Using Freeze-Dried Alginate Gel Combined With Polyglycolic Acid Mesh in a Rat Model
2021, Sexual MedicineCitation Excerpt :However, there are several limitations to the tubular artificial nerve materials, including a need for a device of various diameters depending on the nerve diameter to be regenerated, the inapplicability of the device to damaged sites that are branched into a Y-shape or the plexus type of branched nerves, and the necessity of suturing. In order to overcome these limitations, we developed a novel artificial nerve sheet made of alginate gel (ALG), which is shown to successfully achieve to fill the 50 mm gap in a cat sciatic nerve model.6 Since it is a sheet, it can be used with nerves of various diameters and with complex branches or plexus such as the cavernous nerve plexus.