Central NO is involved in the antinociceptive action of intracisternal antidepressants in freely moving rats
Section snippets
Acknowledgements
This paper was supported by the academic research fund of the Ministry of Education, Republic of Korea (97-227), 1997.
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The glial-neuronal GRK2 pathway participates in the development of trigeminal neuropathic pain in rats
2014, Journal of PainCitation Excerpt :For intracisternal administration in the rat model, the individual rats were anesthetized with a mixture of ketamine (0.2 g/kg) and xylazine (0.02 g/kg). Each anesthetized rat was mounted on a stereotaxic frame, and a polyethylene tube (PE 10) was implanted, as described previously.2,3,25,47,56 The polyethylene tube was inserted through a tiny hole made in the atlantooccipital membrane and dura using a 27-gauge syringe needle.
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2013, Progress in Neuro-Psychopharmacology and Biological PsychiatryBlockade of microglial activation reduces mechanical allodynia in rats with compression of the trigeminal ganglion
2012, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :For intracisternal injections, individual rats were anesthetized and mounted onto a stereotaxic frame. A polyethylene tube (PE 10; Clay Adams, Parsippany, NJ) was implanted on postoperative day 12, as described previously (Ahn et al., 1998, 2005; Wang et al., 2002; Yaksh and Rudy, 1976). The polyethylene tube was inserted through a tiny hole made in the atlanto-occipital membrane and dura with a 27-gauge syringe needle.
The role of nitric oxide in orofacial pain
2012, Nitric Oxide - Biology and ChemistryCitation Excerpt :Similarly, Pena-dos-Santos et al. have explained anti-nociceptive effect of the drug 15d-PGJ(2) in the TMJ inflammatory pain conditions by peripheral opioids receptor, which involves the activation of the intracellular l-arginine/NO pathway [56]. In addition, evidence suggests that intracisternal antidepressants produce antinociception through central NO pathway in the orofacial area [57]. Melatonin can reduce the number of NOS-positive cells in the Vc and produces substantial attenuation of trigeminovascular nociception induced by cortical spreading depression [58].
Nucleus accumbens facilitates nociception
2011, Experimental NeurologyCitation Excerpt :Pre-intervention baseline amplitude was defined as the average of the last three data points, recorded at 5-minute intervals, before an experimental intervention. As is customary for JOR studies (Ahn, et al., 1998, Banks, et al., 1992, Belforte, et al., 2001, Chiang, et al., 1990, 1991, Gear, et al., 1999, Gear and Levine, 1995, Schmidt, et al., 2001, Takeda, et al., 1998, Zhang, et al., 1998, 1999), data were normalized for differences in baseline by calculating the percentage change from baseline for each post-intervention data point. These values were used in the statistical analyses and were also plotted (mean ± s.e.m.) in the figures such that JOR attenuation is represented on the y-axis as positive numbers (i.e., antinociception); JOR enhancement (i.e., “hyperalgesia”) is represented as negative numbers.
5-HT2C receptor agonists attenuate pain-related behaviour in a rat model of trigeminal neuropathic pain
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