Scientific articleEffects of estrogen on the condylar cartilage of the rat mandible in organ culture☆,☆☆
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Cited by (35)
The effect of oestrogen on mandibular condylar cartilage via hypoxia-inducible factor-2α during osteoarthritis development
2020, BoneCitation Excerpt :It has been suggested that oestrogen plays an important role in maintaining condylar cartilage homeostasis and influencing the progression of TMJ OA. Several in vitro studies of condylar chondrocytes or condylar cartilage have shown that the treatment of supra-physiological E2 (10−6 M) could significantly inhibit the chondrocyte proliferation, DNA and proteoglycan synthesis of mandibular condylar chondrocytes, decrease the expression of extracellular matrix (proteoglycan) and cartilage thickness, and up-regulate the expression of pro-inflammatory cytokines (IL-1β, IL-6 and IL-8) and hypertrophic factors (Col X) [26–29]. These results suggest that excessive oestrogen has the potential to cause degenerative changes of condylar cartilage.
Differential effects of high-physiological oestrogen on the degeneration of mandibular condylar cartilage and subchondral bone
2018, BoneCitation Excerpt :An in vitro study has shown that the proliferation, DNA and proteoglycan synthesis of mandibular condylar chondrocytes were inhibited significantly through treatment with supra-physiological E2 (10−6 M) [13]. Similarly, in vitro studies of condylar cartilage organ culture have suggested that supra-physiological E2 (10−8 M, 10−6 M) can inhibit chondrocyte proliferation and decrease extracellular matrix (proteoglycan), leading to decreased cartilage thickness [12,36]. In addition, the expression levels of IL-1β, IL-6 and IL-8 increased in condylar cartilage cultures with increasing concentrations of 17β-estradiol, which suggested that oestrogen has the potential to cause TMD by inducing pro-inflammatory cytokines [37].
Is oestrogen associated with mandibular condylar resorption? A systematic review
2017, International Journal of Oral and Maxillofacial SurgeryCitation Excerpt :Within the scope of potential prevention, these studies illustrated that bone resorption and inflammation could be partially reversed by oestrogen substitution51,53,62,63, which could be related to the positive effect of 17β-oestradiol on OPG transcription and its inhibitory effect on the release of tumour necrosis factor alpha (TNF-α)21. However, oestrogen levels beyond the normal physiological parameters of the cell have been shown to alter cellular metabolism in osteoblasts and chondroblasts13,63. Although it appears to be suggested that a lack of oestrogen should be considered a risk factor for condylar resorption, the clinical studies included on this topic did not show a significant correlation between oestrogen levels and postoperative relapse7,16,18.
Sex differences in the estrogen-dependent regulation of temporomandibular joint remodeling in altered loading
2017, Osteoarthritis and CartilageCitation Excerpt :Afterwards, they either continue to proliferate or proceed through cell cycle arrest to then differentiate into chondrocytes which express collagen type II and aggrecan18,21. This process is further regulated by estrogen signaling22–24 which predominantly occurs through two receptor isoforms, estrogen receptor alpha (ERα) and beta (ERβ). Ligand binding of estrogen to either receptor induces a conformational change, receptor dimerization, nuclear translocation, and target gene transcription.
Pathogenesis of Osteoarthritis
2016, Kelley and Firestein's Textbook of Rheumatology: Volumes 1-2, Tenth Edition
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Received from Baylor College of Dentistry, a member of the Texas A&M University System, Dallas, TX.
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This study was supported by BCD-TAMUS intramural research and the Center for Craniofacial Research and Diagnosis Funds.
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Instructor, Department of Biomedical Sciences.
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Assistant Professor, Department of Oral and Maxillofacial Surgery/ Pharmacology, and Department of Biomedical Sciences.
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Associate Professor, Department of Biomedical Sciences.