The clinical spectrum of anti-Ro-positive cutaneous neonatal lupus erythematosus☆,☆☆,★
Section snippets
SUBJECTS AND METHODS
All 18 babies were seen within the first 2 months of life by one of the authors at the University of Colorado Health Sciences Center. All 18 babies and their mothers had anti-Ro (anti-SS-A) autoantibodies in their sera. A retrospective chart analysis was undertaken and examined for age at onset, distribution and type of skin lesions, history of sun-induced lesions, duration of lesions, residual lesions on follow-up examinations at least 3 years later, and presence of extracutaneous involvement.
RESULTS
This group comprised 14 female and 4 male infants. Fourteen were white, 2 black, 1 Hispanic, and 1 Asian. This is similar to the racial demographics of Colorado. Facial lesions were observed in 17 of 18 with the characteristic periorbital “owl-eye” or “eye mask” facial rash (Fig 1) seen in 14. Involvement of the scalp was observed in 15, of the arms and legs in 13, and of the trunk and groin in 6. Crusted lesions
DISCUSSION
Although neonatal lupus is being increasingly recognized, in virtually none of the babies in this series was the diagnosis of NLE initially suspected. The characteristic periorbital “owl-eye” appearance was present in the majority of babies and we believe should be strongly emphasized as a cutaneous clue to NLE. However, the absence of the distinctive facial rash does not exclude the diagnosis of NLE. We observed thickly crusted facial and extremity lesions in 3 babies who did not have this
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Cutaneous sequelae in neonatal lupus: A retrospective cohort study
2020, Journal of the American Academy of DermatologyCitation Excerpt :Atrophic scarring is the most worrisome complication of CNLE given the higher likelihood of persistence and lack of effective therapies available. Scarring is scarcely reported in CNLE; Weston et al7 found no atrophy or scarring developed in their 18 patients. Neiman et al,9 however, found that 10 of 51 patients had pitting, scarring, or atrophy after a minimum 2 years of follow-up.
Polymorphism and differential diagnosis of neonatal lupus erythematosus
2020, Annales de Dermatologie et de VenereologieNeonatal lupus syndrome induced by anti-ribonucleoprotein antibodies
2016, Medicina ClinicaNeonatal Lupus Erythematosus
2015, Textbook of Pediatric Rheumatology
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Supported by grant R03 DK 53754 from the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health.
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Reprints are not available from the authors.
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