Letter to the editor
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Cited by (15)
Effects of hyaluronan on vascular endothelial growth factor and receptor-2 expression in a rabbit osteoarthritis model
2009, Journal of Orthopaedic ScienceEfficacy of Hylan G-F 20 and Sodium Hyaluronate in the treatment of osteoarthritis of the knee - A prospective randomized clinical trial
2008, KneeCitation Excerpt :Whilst there is a general acceptance of the beneficial effects of HA, there still exists an ongoing debate about the degree of efficacy of these individual products [15,17]. Additionally there have been controversies in the therapeutic efficacy of cross-linked/non cross-linked and high/low molecular weight products [10,15,20,21,45]. This has prompted the need for well designed prospective randomized trials to resolve the continued uncertainty about the magnitude of therapeutic effects of various products.
What is important in treating osteoarthritis? Whom should we treat and how should we treat them?
2003, Rheumatic Disease Clinics of North AmericaIntra-articular hyaluronans: A review of product-specific safety profiles
2003, Seminars in Arthritis and RheumatismCitation Excerpt :Hyalgan was well tolerated in this population, with only 17 adverse events reported. These included local reaction to puncture (5), exudation in the articular space (6), local swelling (2), gastric discomfort (2), and allergic exanthema (1). Despite the excellent tolerability profile of Hyalgan shown in clinical trials and observed in clinical experience, there has been at least 1 published case study of a patient with calcium pyrophosphate dihydrate (CPPD) arthritis (pseudogout) presumably resulting from an IA injection of Hyalgan (20); 2 additional reports did not specify which HA product was used (21,22).
High molecular weight hyaluronan promotes repair of IL-1β-damaged cartilage explants from both young and old bovines
2003, Osteoarthritis and CartilageComplex fluids based on methacrylated hyaluronic acid
2010, Biomacromolecules