Elsevier

The Lancet

Volume 329, Issue 8529, 14 February 1987, Pages 355-357
The Lancet

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

https://doi.org/10.1016/S0140-6736(87)91728-4Get rights and content

Abstract

Serum samples taken on admission from 79 patients with meningococcal meningitis, septicaemia, or both, were examined in a highly sensitive bioassay for tumour necrosis factor (TNF). TNF was detected in samples from 10 of 11 patients who died but from only 8 of 68 survivors. All 5 patients with serum TNF levels over 440 units/ml (corresponding to 0·1 ng/ml recombinant TNF) died.

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