Letters to the EditorAGE-RELATED INCREASE IN AUTOANTIBODIES
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Cited by (67)
Serum titers of autoantibodies against α-synuclein and tau in child- and adulthood
2018, Journal of NeuroimmunologyHypothyroid Symptoms Fail to Predict Thyroid Insufficiency in Old People: A Population-Based Case-Control Study
2016, American Journal of MedicineThe clinical utility of a positive antinuclear antibody test result
2013, American Journal of MedicineCitation Excerpt :Only 5 patients were diagnosed with lupus, the disease that was generally being screened for when an ANA was ordered; the positive predictive value for any positive ANA with regard to systemic lupus erythematosus only was 2.1% for the entire cohort (positive predictive value = 2.9% for ANA ≥ 1:160). Although the prevalence of clinically unimportant positive ANA test results reportedly is increased in older populations,11-13 the positive predictive value of a positive ANA test result was not greater among the younger patients in our cohort. By using < 65 years of age as a cutoff separating younger from older subjects (Table 3), 17 of 192 patients in the younger subgroup had an antinuclear antibody-associated rheumatic disease (positive predictive value = 8.9%) versus 4 of 40 subjects in the older group (positive predictive value = 10%).
Iodine deficiency influences thyroid autoimmunity in old age - A comparative population-based study
2012, MaturitasCitation Excerpt :Also, the adaptive immune system is influenced by age through thymic involution with decreasing production of naive T-cells, and signalling defects in elderly T-cells and B-cells have been suggested [6,25]. Thus, autoantibodies are common in old age [8,9], but whether this is due to immune aging or related to prolonged environmental challenges is not known. Age influences the prevalence of TGAb and TPOAb.
The initial manifestations and final diagnosis of patients with high and low titers of antinuclear antibodies after 6 months of follow-up
2011, Journal of Microbiology, Immunology and Infection