ArticlesA comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Introduction
Measurement of the burden of diseases and injuries is a crucial input into health policy. Equally as important, is a comparative assessment of the contribution of potentially modifiable risk factors for these diseases and injuries. The attribution of disease burden to various risk factors provides a different account compared with disease-by-disease analysis of the key drivers of patterns and trends in health. It is essential for informing prevention of disease and injury.
Understanding the contribution of risk factors to disease burden has motivated several comparative studies in the past few decades. The seminal work of Doll and Peto1 provided a comparative assessment of the importance of different exposures, particularly tobacco smoking, in causing cancer. Peto and colleagues2 subsequently estimated the effects of tobacco smoking on mortality in developed countries since 1950. Although these risk factor-specific or cause-specific analyses are useful for policy, a more comprehensive global assessment of burden of disease attributable to risk factors can strengthen the basis for action to reduce disease burden and promote health. The Global Burden of Disease Study (GBD) 1990 provided the first global and regional comparative assessment of mortality and disability-adjusted life-years (DALYs) attributable to ten major risk factors.3 However, different epidemiological traditions for different risks limited the comparability of the results. Subsequently, Murray and Lopez4 proposed a framework for global comparative risk assessment, which laid the basis for assessment of 26 risks in 2000.5, 6, 7 Since this work, WHO has provided estimates for some risks by the same methods but with updated exposures and some updates of the effect sizes for each risk.8 Analyses have also been done for specific clusters of diseases, like cancers,9 or clusters of risk factors, like maternal and child under-nutrition.10 National comparative risk assessments (including in Australia, Iran, Japan, Mexico, South Africa, Thailand, USA, and Vietnam) have also been undertaken with similar approaches.11, 12, 13, 14, 15, 16
GBD 2010 provides an opportunity to re-assess the evidence for exposure and effect sizes of risks for a broad set of risk factors by use of a common framework and methods. Particularly, since this work was done in parallel with a complete re-assessment of the burden of diseases and injuries in 1990 and 2010, for the first time changes in burden of disease attributable to different risk factors can be analysed over time with comparable methods. Since uncertainty has been estimated for each disease or injury outcome,17, 18 the comparative risk assessment for GBD 2010 has also enabled us to incorporate uncertainty into the final estimates. We describe the general approach and high-level findings for comparison of the importance of 67 risk factors and clusters of risk factors, globally and for 21 regions of the world, over the past two decades.
Section snippets
Overview
The basic approach for the GBD 2010 comparative risk assessment is to calculate the proportion of deaths or disease burden caused by specific risk factors—eg, ischaemic heart disease caused by increased blood pressure—holding other independent factors unchanged. These calculations were done for 20 age groups, both sexes, and 187 countries and for 1990, 2005 (results for 2005 not shown, available from authors on request), and 2010. We present aggregated results for 21 regions.
Table 1 shows the
Results
Quantification of risk factors in this analysis represents the effects of each individual risk factor, holding all other independent factors constant. The effects of multiple risk factors are not a simple addition of the individual effects and are often smaller than their sums,156 especially for cardiovascular diseases, which are affected by several risk factors (eg, table 2). The sum of the individual effects of just the metabolic risk factors at the global level is 121% and the summation of
Discussion
The results of GBD 2010 suggest that the contributions of risk factors to regional and global burden of diseases and injuries has shifted substantially between 1990, and 2010, from risk factors that mainly cause communicable diseases in children to risk factors that mainly cause non-communicable diseases in adults. The proportion of overall disease burden attributable to childhood underweight—the leading risk factor worldwide in 1990—had more than halved by 2010, making childhood underweight
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