CommentClinical update: treating osteoarthritis
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2021, iScienceCitation Excerpt :The disease is characterized by the degradation of the articular cartilage, which results in impaired joint functionality (Felson, 2006). Current therapies provide symptomatic relief but are unable to cure the disease, and patients eventually require total joint replacement (Lohmander and Roos, 2007). The search for new OA treatment options focuses on regenerative cell therapies, among others modalities (Brittberg et al., 1994; Schminke and Miosge, 2014).
Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration
2021, BiomaterialsCitation Excerpt :Deterioration of the OA condition can only be treated with surgeries, including total joint replacement by a prosthetic joint [7,8]. Cell therapies represent a new generation of OA treatment [12,13]. Options include transplanting plugs of cartilage isolated from non-weight-bearing areas to the defect site (mosaicplasty) [7,14], autologous chondrocyte transplantation using cultured chondrocytes isolated from a cartilage biopsy [7,8], and inducing regeneration of a fibrous type of cartilage by drilling through the subchondral bone to release marrow elements [8,14].
Extra-articular location of the three-dimensional mechanical axis in advanced knee osteoarthritis: an upright computed tomography study
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